Indoleamine 2,3-Dioxygenase (IDO) Inhibitors

IDO1

IDO2

IDO

Indoleamine 2,3-Dioxygenase (IDO) Inhibitors & Degraders

상품명	IDO1	IDO2	IDO	Purity
Epacadostat	IDO1, IC₅₀: 71.8 nM			99.72%
Indoximod			IDO, Ki: 19 μM	99.85%
IDO1/TDO-IN-15	IDO1, IC₅₀: 0.19 μM
Palmatine chloride	IDO-1, IC₅₀: 3 μM (HEK 293-hIDO-1) IDO-1, IC₅₀: 157 μM (rhIDO-1)			99.87%
Linrodostat	IDO1, IC₅₀: 1.1 nM			99.81%
PF-06840003	IDO-1			99.87%
Coptisine chloride			IDO, IC₅₀: 6.3 μM IDO, Ki: 5.8 μM	99.73%
IDO-IN-7	IDO1, IC₅₀: 38 nM			99.80%
IDO1/TDO-IN-4	IDO1, IC₅₀: 3.53 μM			99.74%
(Rac)-Indoximod			IDO	99.60%
Navoximod			IDO, EC₅₀: 75 nM IDO, Ki: 7 nM	99.99%
LY-3381916	IDO1			99.92%
PROTAC IDO1 Degrader-1	IDO1, DC₅₀: 2.84 μM IDO1, IC₅₀: 1.07 μM			99.00%
Palmatine hydroxide	IDO-1, IC₅₀: 3 μM (HEK 293-hIDO-1) IDO-1, IC₅₀: 157 μM (rhIDO-1)			99.64%
DP00477	IDO1, IC₅₀: 7.0 μM			98.21%
PCC0208009			IDO, IC₅₀: 4.52 nM (in HeLa cell)	98.06%
IDO5L			IDO, IC₅₀: 67 nM IDO, IC₅₀: 19 nM (in HeLa cell)	99.89%
GNF-PF-3777		rhIDO2, IC₅₀: 1.8 μM rhIDO2, Ki: 0.97 μM		98.03%
IDO1/2-IN-1	IDO1, IC₅₀: 28 nM	IDO2, IC₅₀: 144 nM		98.06%
IDO1-IN-19	IDO1			98.82%
NU223612	IDO1, Kd: 640 nM			99.41%
BMS-986242	IDO1			98.85%
IDO2-IN-1	IDO1, IC₅₀: 411 nM	IDO2, IC₅₀: 112		98.10%
IDO-IN-1			IDO, IC₅₀: 59 nM IDO, IC₅₀: 12 nM (in HeLa cell)	98.14%
2-Hydrazinobenzothiazole	IDO1, IC₅₀: 8 μM			99.95%
IDO1-IN-28	apo-IDO1, IC₅₀: 1.29 μM			99.89%
BMS-978587	IDO-1			99.92%
IDO-IN-5			IDO, IC₅₀: 1-10 μM	99.90%
IDO-IN-8			IDO, IC₅₀: 1-10 μM	99.99%
NU227326	IDO1, DC₅₀: 4.5 nM
IDO-IN-3			IDO, IC₅₀: 290 nM IDO, IC₅₀: 98 nM (in HeLa cell)	98.97%
Coptisine			IDO, IC₅₀: 6.3 μM IDO, Ki: 5.8 μM
BMT-297376	IDO1			99.14%
Amg-1	IDO1, IC₅₀: 3.0 μM	IDO2, IC₅₀: >250 μM
Palmatine	IDO-1, IC₅₀: 3 μM (HEK 293-hIDO-1) IDO-1, IC₅₀: 157 μM (rhIDO-1)
IDO-IN-6			IDO, IC₅₀: 1 μM	99.80%
IDO1 and HDAC1 Inhibitor	IDO1, IC₅₀: 69.0 nM
IDO-IN-9			IDO, IC₅₀: 11 nM IDO, IC₅₀: 1.8 nM (in Hela cell)
IDO-IN-11			IDO, IC₅₀: 180 nM IDO, IC₅₀: 14 nM (in Hela cell)
IDO1-IN-17	IDO1, IC₅₀: 0.44 μM (in hela cells)
ZC0101	IDO1, IC₅₀: 0.084 μM
MMG-0358	IDO1, IC₅₀: 330 nM
IDO1/TDO-IN-8	IDO1, EC₅₀: 0.33 μM
CAY10581			IDO, IC₅₀: 55 nM
IDO1/TDO-IN-12	IDO1, IC₅₀: 0.825 μM
IDO1/TDO-IN-16	IDO1
IDO/TDO-IN-2	IDO1
IDO1-IN-37	IDO1, IC₅₀: 0.106 μM
iDeg-3	IDO1
IDO1-IN-34	IDO1, IC₅₀: 0.093 μM
IDO1-IN-29	apo-IDO1, IC₅₀: 0.29 μM
Roxyl-9	IDO1			99.22%
IDO1/TDO-IN-17	IDO1, IC₅₀: ~280 μM
(E)-IDO1/TDO-IN-15	IDO1
NAMPT/IDO1-IN-1	IDO1, IC₅₀: 233 nM
IDO1-IN-21	IDO1, IC₅₀: 0.64 μM
IDO1 ligand-1	IDO1
IDO1-IN-13	IDO1, IC₅₀: 30 nM
NDs-IN-1	IDO-1
iDeg-6	IDO1
IDO1/TDO-IN-1	IDO1, Ki: 0.23 μM
TDO-IN-3	IDO1, IC₅₀: 4.12 μM
1-Isopropyltryptophan	IDO1
IDO1-IN-27	hIDO1, IC₅₀: 0.3951 μM
IDO1-IN-15	IDO1, IC₅₀: 127 nM
IDO1/TDO-IN-11	hIDO1, IC₅₀: 2.87 μM
IDO1-IN-35	IDO1
IDO1-IN-36	hIDO1, IC₅₀: 0.72 μM
8-F-2-(Me-Pip-Me)-Tryptanthrin	IDO1	IDO2
IDO1-IN-31	IDO1, IC₅₀: 77 nM
IDO1/TDO-IN-5	IDO1, IC₅₀: 18 nM
IDO1-IN-2	IDO1, IC₅₀: 81 nM
IDO1-IN-33	IDO1, IC₅₀: 0.18 μM
IDO1-IN-32	IDO1, IC₅₀: 10 pM
IDO1-IN-16	IDO1, IC₅₀: 127 nM
IDO1-IN-14	IDO1, EC₅₀: 396.9 nM
1,2-Didehydrotanshinone IIA			IDO, IC₅₀: 4.68 μM
IDO1-IN-26	IDO1			98.22%
Linrodostat mesylate	IDO1, IC₅₀: 1.1 nM
LW106	IDO1, IC₅₀: 1.57 μM

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